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NMN mitigates age-associated physiological decline / β-烟酰胺单核苷酸减缓衰老相关的生理衰退
Long term administration of NMN on normal wild-type mice demonstrates that NMN effectively mitigates age-associated physiological decline in mice without any obvious toxicity. These results highlight the significant potential of NMN as an effective anti-aging intervention in bodies.
넶0 2023-06-27 -
Oral NMN Is Safe and Efficiently Increases / NAD+ 口服NMN安全并且有效增加体内NAD+
In this study, we conducted a placebo-controlled, randomized, double blind, parallel-group trial to investigate the safety of orally administered NMN and its efficacy to increase NAD+ levels in thirty healthy subjects. Healthy volunteers received 250 mg/day of NMN (n = 15) or placebo (n = 15) for 12 weeks, and physiological and laboratory tests were performed during this period. In addition, NAD+ and its related metabolites in whole blood were examined.
넶0 2023-06-27 -
Why NMN is main NAD precursor? / 为何NMN是主要的NAD前体物质？
Salvage pathway is the key pathway for maintaining cellular NAD+ levels. The NAD+-consuming enzymes—the SIRTs, ARTs, and PARPs—all generate nicotinamide as a by-product of their enzymatic activities. Nicotinamide regulates their activities as an inhibitory factor by binding in a conserved NAD+ pocket and also as a biosynthetic precursor to NAD+ via activity of nicotinamide phosphoribosyltransferase (NAMPT).
넶0 2023-06-27 -
Why NAD+ need to be supplemented? / 体内NAD+为何需要补充？
NAD+ is required not only for life but for a long life. In this issue, Camacho-Pereira et al. implicate CD38 in the decline of NAD+ during aging, with implications for combating age-related diseases.
넶0 2023-06-27 -
Supplement of NAD precursor NMN delays aging / 补充NAD前体NMN延缓衰老
Why do NAD levels decrease with age? Camacho et al. now reveal that increased expression of the NADase CD38 is responsible for NAD decline and mitochondrial dysfunction in older mice in an SIRT3-dependent manner. CD38 also metabolizes the NAD precursor NMN and modulates the response to NAD-replacement therapy in vivo.
넶0 2023-06-27 -
NMN enhances oxidative metabolism and protects against obesity / β-烟酰胺单核苷酸增强氧化代谢预防肥胖
NMN increase NAD+ content in key metabolic tissues, leading to SIRT1 and SIRT3 activation and the deacetylation and modulation of the activity of key metabolic regulators. This model does not rule out the participation of additional mechanisms of action for NR to achieve its beneficial effects. Abbreviations can be found in the text, and enzymes are indicated in italics.
넶0 2023-06-27 -
NMN treatment protected against cardiac dysfunction / β-烟酰胺单核苷酸防止心脏功能障碍
NMN treatment protected against cardiac dysfunction in a Friedreich’s ataxia cardiomyopathy mouse model in a SIRT3-dependent manner and increased cardiac function in Ndufs4 knockout mice exposed to pressure overload64. NR treatment also reduced inflammation and fibrosis in aged MDX mice, a muscular dystrophy model that develops cardiomyopathy. Finally, PARP inhibitors protected against hypertrophy and improved cardiac function in several rodent models, possibly in part by increasing NAD+ levels.
넶0 2023-06-27 -
NMN treatment protected against cardiac dysfunction / β-烟酰胺单核苷酸防止心脏功能障碍
NMN treatment protected against cardiac dysfunction in a Friedreich’s ataxia cardiomyopathy mouse model in a SIRT3-dependent manner and increased cardiac function in Ndufs4 knockout mice exposed to pressure overload64. NR treatment also reduced inflammation and fibrosis in aged MDX mice, a muscular dystrophy model that develops cardiomyopathy. Finally, PARP inhibitors protected against hypertrophy and improved cardiac function in several rodent models, possibly in part by increasing NAD+ levels.
넶0 2023-06-27 -
NAD+ directly regulates protein-protein ...... / NAD+直接调节蛋白之间相互作用从而预防癌变、辐射和衰老
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions.
넶0 2023-06-29 -
NMN improve mitochondrial bioenergetics...... / NMN提升线粒体活力，逆转年老衰退，抑制缺血后NAD+降解和细胞死亡
Administration of NMN has shown to improve mitochondrial bioenergetics, reverse age‐associated physiological decline, and inhibit postischemic NAD+ degradation and cellular death. In this study, we identified a novel link between NAD+ metabolism and mitochondrial dynamics. A single dose (62.5 mg/kg) of NMN, administered to male mice, increases hippocampal mitochondria NAD+ pools for up to 24 hr posttreatment and drives a sirtuin 3 (SIRT3)-mediated
넶0 2023-06-29
- 2023-06-29
- 2023-06-29
- 2023-06-27
- 2023-06-27
