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NMN improve mitochondrial bioenergetics...... / NMN提升线粒体活力，逆转年老衰退，抑制缺血后NAD+降解和细胞死亡
Administration of NMN has shown to improve mitochondrial bioenergetics, reverse age‐associated physiological decline, and inhibit postischemic NAD+ degradation and cellular death. In this study, we identified a novel link between NAD+ metabolism and mitochondrial dynamics. A single dose (62.5 mg/kg) of NMN, administered to male mice, increases hippocampal mitochondria NAD+ pools for up to 24 hr posttreatment and drives a sirtuin 3 (SIRT3)-mediated2023-06-29
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NAD+ directly regulates protein-protein ...... / NAD+直接调节蛋白之间相互作用从而预防癌变、辐射和衰老
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions.2023-06-29
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NMN treatment protected against cardiac dysfunction / β-烟酰胺单核苷酸防止心脏功能障碍
NMN treatment protected against cardiac dysfunction in a Friedreich’s ataxia cardiomyopathy mouse model in a SIRT3-dependent manner and increased cardiac function in Ndufs4 knockout mice exposed to pressure overload64. NR treatment also reduced inflammation and fibrosis in aged MDX mice, a muscular dystrophy model that develops cardiomyopathy. Finally, PARP inhibitors protected against hypertrophy and improved cardiac function in several rodent models, possibly in part by increasing NAD+ levels.2023-06-27
